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The phagocytized non-photosynthetic bacteria (symbionts) over eons evolved into mitochondria while the engulfed photosynthesizing bacteria became chloroplasts (known as the well-established endosymbiotic theory) of the early eukaryotes and during this process the melatonin-synthesizing capacity of the bacteria-derived organelles, both chloroplasts and mitochondria, was retained ( Figure 2 )

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Reactive oxygen species signaling and oxidative stress: Transcriptional regulation and evolution

About 40% of hepatic transcriptomics exhibit circadian oscillations [91] , including rhythms in protein levels, posttranslational modifications, and several metabolites in mammals [92,93]