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Substrate-induced transmembrane signaling in the cobalamin transporter BtuB

Total cholesterol levels at the end of our study in the control DIO mice were comparable to cholesterol levels reported by the vendor for age-matched DIO mice

Methylcobalamin is the most active form of Vitamin B12, which is better absorbed and utilized by the body (most Vitamin B12 injections are Cyanocobalamin-the cheapest, synthetic form of Vit B12)

Surgery is reserved for cases that fail 3-6 months of well-structured conservative care, when there is structural pathology (severe deformity, complete tear, advanced arthritis), or when imaging shows damage that will not heal without intervention