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414 The pathogenesis of autoimmune diseases includes genetic factors, cross-antigens, abnormal immune regulation and autoantigens

Data availability The datasets generated during the current study are available from the corresponding author on reasonable request

A crossbreeding experiment utilizing the maternal inheritance of mtDNA verified the novel variant as the determinant of the survival difference

Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A: Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor 1/insulin signaling and caloric restriction