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[DOI] [PMC free article] [PubMed] [Google Scholar] 404.Huang J, Chen X, Jiang Y, Zhang C, He S, Wang H and Pu K, Nat

While there is no corroborative clinical trial data, animal experiments suggest that hydroxocobalamin produces a time and organdependent, selective regulation of nitric oxide synthases during endotoxemia and regulates downstream inflammatory mediators, thereby having a potential role in the treatment septic shock 4

Oxidative stress and inflammation are key contributors to the pathophysiology of CAD, including atherosclerosis and ischemic damage (Pashkow 2011)

These properties play a crucial role in determining their pharmacokinetic properties as well as in the range of biomedical applications