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For example, the activity of a protein and/or one or more natural binding partners can be determined by: detecting induction of a second messenger in the cell (e.g., intracellular signaling), detecting catalytic/enzymatic activity of an appropriate substrate, detecting induction of a reporter gene comprising a target reactive regulatory element operably linked to a nucleic acid encoding a detectable marker (e.g., chloramphenicol acetyl transferase), or detecting a cellular response regulated by a protein and/or one or more natural binding partners

NETs may also activate immune cells to target autoantigens, prompting interferon to trigger an inflammatory response and the formation of interferon immune complexes (66)

Radioiodine Uptake and Scan : Evaluating the functional status and distribution of thyroid activity

In this experiment, species distributions at the phylogenetic, class, and family levels were analyzed using column charts