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doi: 10.2337/db21-0261 75 XinYDominguez GutierrezGOkamotoHKimJLeeAHAdlerCet al

1 Introduction Alzheimers disease (AD) is a progressive and multifactorial neurodegenerative disorder that predominantly affects the elderly population, manifesting as severe cognitive decline, memory impairment, and behavioral disturbance (Tripathi et al., 2024)