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Earlier this year, the FDA granted ibrutinib a Breakthrough Therapy Designation for patients with chronic GVHD that is not being controlled by other therapies like corticosteroids

doi: 10.1038/kisup.2012.7

Besides, numerous studies have showed that inhibition of GPX4 could increase the sensitivity of chemotherapy, radiotherapy, immunotherapy and nanotherapy by inducing lipid peroxidation and ferroptosis [227,228,229]

In the case of congenital blindness, since the visual system has received no (or very little) light stimulation, there is significant cross-modal plasticity such that visual areas instead respond to auditory (Coullon et al