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Immunologically active substances, including natural active compounds, small molecule compounds, and repurposed drugs, have achieved satisfactory results in vitro experiments, animal experiments, or clinical trials

The swelling of mitochondria, the dilatation of intercellular space and the dilatation of inner plasma can be seen clearly in electron microscope (9)

Furthermore, Ca 2+ -dependent C2 membrane binding disrupts C2/HECT interactions, but not Ca 2+ alone, whereas 14-3-3 protein binds to a flexible region of Nedd4-2 containing the WW2 and WW3 domains, thereby inhibiting its catalytic activity and membrane binding

Gallo called the virus "human T-lymphotropic virus type III" (HTLV-III) because of perceived similarities with HTLV-I and -II, which had previously been discovered in his lab