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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

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Folate (Vitamin B9) is particularly important for women of childbearing age

Notably, one of the initial investigations that introduced seaweed as a dietary component for chickens demonstrated that Ulva seaweed feeding resulted in reduced growth when included as 10% of the total diet, owing to its substantial unmetabolizable polysaccharide content (70)