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Xu M, Tao J, Yang Y, Tan S, Liu H, Jiang J, et al

It acts via Fenton reaction and utilizes the intracellular overproduced H 2 O 2 to generate the ROS, which leads to toxic effect in cancer cells

By combining single-cell transcriptome sequencing (scRNA-seq) with lactate/lactylation proteomic analysis, it will be possible to precisely distinguish the lactate/lactylation characteristics of different cell subgroups, such as NP and AF cells