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When the immune system is already dysregulated, introducing compounds that modulate immune function carries inherent risks

AOD9604 and Energy Balance Research In obese ob/ob and lean C57BL/6J mice treated for 14 days via mini-osmotic pumps, AOD9604 significantly reduced body weight gain in obese mice, associated with increased in vivo fat oxidation and increased plasma glycerol levels as an index of enhanced lipolysis without the hyperglycaemia or reduced insulin secretion associated with intact hGH treatment

These findings indicate that ATF4 does not contribute to GLUT1 regulation in intestinal tissues