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Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

Typically, patients report complaints of both pain and paresthesia in the distribution area of the median nerve, which includes the palmar surface of the thumb, the radial part of the ring finger, and the index and middle fingers

Previous studies have also shown that GDF11 is widely expressed in both neurons and glial cells (Liang et al., 2014), and some studies have shown that GDF11 affects neurogenesis and modulates neurons morphology (Gokoffski et al., 2011

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