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On the other hand, it is possible that the inert carriers generated from the cleavage of the prodrug are converted into toxic metabolites, such as formaldehyde and acetaldehyde

For instance, LPS activates macrophages and induces the production of pro-inflammatory cytokines such as TNF- and IL-6 216 (Fig

Am J Manag Care 28:S188S196

These findings indicate that there might be a considerable number of unrecognized processes and mechanisms involved in the genes encoding the GST isoenzymes, which when disrupted, could contribute to cardiovascular diseases