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For the rotarod assay, forelimb grip strength test, and neurophysiology CMAP recordings, there was no significant difference throughout disease progression over the course of 47 days between treated and untreated groups (Fig

Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells

High activity of TGF- [187, 188], histone deacetylase 8 (HDAC8) [189], p21-activated kinase 4 (PAK4) [190, 191], protein phosphatase 2 A (PP2A) [192], cyclin-dependent kinase 4/6 (CDK4/6) [160, 193], orphan GPR182 [194], and WNT/-catenin [195,196,197], as well as loss of phosphatase and tensin homolog (PTEN) [198,199,200], hamper CD8 + T-cell infiltration and promote their exclusion