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Because ergosterol directly promotes the growth of fungal cells in a hormonelike fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth

Proteasomal processing results in complete proteolysis of the substrate, while deubiquitinating enzymes (DUBs) recycle ubiquitin molecules for subsequent rounds of degradation, ensuring the efficiency and sustainability of the pathway

However, due to the limited number of human studies, particularly long-term evaluations, potential side effects cannot be completely ruled out

Each DMARD carries specific side effects and particular levels of risk