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10.1080/19490976.2024.2351532 Gut Microbes

Interestingly, investigations into the genetic variance risk related to intrinsic inhibition of TNF or TNFR1-TNF have found no correlation between the age of onset of PD and inhibition of this pathway, indicating that further research is needed to understand the role of necrosis in disease development (Kang et al., 2021)

Thus, Ab binding to DsG-1 and DsG-3 without subsequent immune activation is likely sufficient to cause the pathophysiology

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