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Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig

The Y296 residue has been demonstrated to be involved in a conformational change that occurs with NADPH binding (Silvestri et al., 2018), therefore the mutation of this residue was designed to perturb both formation of the NADPHSmTGR complex and FAD reduction

The reactivation of Ero1 by molecular oxygen generates reactive oxygen species (ROS) in the ER

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