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Description

Nature 406, 775781

Oxidative stress caused by ROS overproduction can contribute to the pathogenesis of IBD by damaging cellular components, activating proinflammatory signaling pathways, and impairing the intestinal epithelial barrier

Specifically, targeting oxidative stress through molecular pathways such as MAPK, TLR4/NF-B, Nrf2, and PI3K/Akt could offer new therapeutic avenues for IBD management

Mutations in Parkin or PINK1 impair these proteins, leading to the accumulation of damaged mitochondria, reduced energy production, and elevated levels of reactive oxygen species (ROS) 39