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527 In lupus-prone mice, CQ promotes the expansion of Treg populations and suppresses CNS inflammation under both prophylactic and therapeutic dosing regimens

The 4-HNE-induced ERK1/2 activation was mediated by repressing mitogen-activated protein kinase phosphatase-1 (MKP-1), a negative regulator of ERK1/2, through a proteasome-dependent degradation mechanism

Phenolic chemicals contained in these mushrooms (such as gallic acid, ferulic acid, and caffeic acid) have an important role in carcinogenesis prevention by reducing free radical formation and altering signaling pathways involved in cell proliferation and death

Studies in Pink1 -deficient Drosophila and mouse models demonstrated that an early consequence of Pink1 deficiency is the disruption of complex I function, leading to mitochondrial membrane depolarization, increased sensitivity to apoptotic stress, and synaptic transmission deficits [90]