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It carries out its cytotoxic action by interacting with DNA and inducing direct damage that leads the cell to apoptosis [101]

A mouse model of X-linked intellectual disability associated with impaired removal of histone methylation

This might suggest that time of day differences exist in the expression of these clock proteins in the lens, with BMAL1 and CLOCK expression more abundant during the day (10am) relative to CRY and PER expression