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This feedback loop is essential for creating the specific microenvironment that allows for endometrial response to estrogen in the proliferative phase, while simultaneously preventing an over-response, leading to endometrial hyperplasia

Dal Pra I, Chiarini A, Pacchiana R, Zumiani G, Zanoni M, Armato U (2007) Comano's (Trentino) thermal water interferes with tumour necrosis factor-alpha expression and interleukin-8 production and secretion by cultured human psoriatic keratinocytes: yet other mechanisms of its anti-psoriatic action

AOD 9604 doesn't affect IGF-1 levels, so there's no concern about unwanted tissue growth or increased cancer risk

By shifting the production toward a lighter form of melanin, it may help reduce the appearance of dark spots and support an even skin tone