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Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia

Palacios G, Muro A, Verd E, Pumarola M, Vela JM

As a first-generation ferroptosis inhibitor, its core mechanism involves direct interception of lipid radicals to terminate peroxidation chain reactions: its arylamine group (-NH-) donates hydrogen atoms (H) to reduce lipid peroxyl radicals (LOO LOOH), a mechanism analogous to vitamin E but with superior ferroptosis-inhibitory efficacy (237)