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An enzyme critical in fatty acid desaturation, Stearoyl-CoA Desaturase 1 ( SCD1 ), had increased DNA methylation near its transcription start site following sleep deprivation in male blood samples (Skuladottir et al., 2016)

Dark circles have two primary causes that are frequently conflated but require different active responses: vascular pooling in the blood vessels around the eye, which produces a bluish-purple discolouration most visible through thin skin in that area, and surface pigmentation from UV exposure, post-inflammatory marks, or accumulated melanin, which produces a brownish discolouration

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