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10.1016/j.bbadis.2015.01.015 20 DerbreF.FerrandoB.Gomez-CabreraM

Mitochondrial ALDH is inactive in at least 40% of the Oriental population

In an in vitro study on human keratoconic stromal cells (keratoconus is an eye disorder that oxidative stress may be implicated in its development), an increased gene expression of antioxidant enzymes (SOD, GPx and CAT) in riboflavin-treated cells (compared with untreated cells) was reported (Reference Cheung, McGhee and Sherwin39)

The increase in OVA preference could not be explained by differences in antibody titres, as the levels of total and OVA-specific IgE as well as OVA-specific IgG1 were similarly induced in isotype- and anti-GDF15-treated groups (Extended Data Fig