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These specialized cells play a pivotal role in hair follicle growth and regeneration by secreting growth factors such as fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF-1), which regulate the proliferation and differentiation of HFSCs [62]

Unlike synthetic carriers employed in conventional drug development, phytochemical-based supramolecular systems offer unique biomimetic properties: transcending bioavailability limitations of traditional formulations, conferring stimulus-responsive behavior, and enabling synergistic therapeutic efficacythereby pioneering novel approaches for precision medicine

In synaptic mitochondria, the major role in control over oxidative phosphorylation is attributed to complex I that at 25% inhibition, energy metabolism is disturbed and ATP synthesis is drastically affected