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These results raise questions about the actual therapeutic window for GlyT1 inhibition, especially regarding duration, dose, and the regional specificity of transporter modulation

Sarris AH, Viviani S, Bonfante V, Kliche KO, Notti P, Peethambaram P, Tucker S, Preti A, Mesina O, Hagemeister F, Romaguera J, McLaughlin P, Rodriguez MA, Andreeff M , Witzig T, Bonadonna G, Cabanillas F

Urinary sulfate excretion was reduced up to 95% by feeding low-methionine diets to rats, and a 60% decrease in liver methionine was observed, [14]

The BTB and IVR domains are required for the redox- and electrophile-sensitive regulation of Nrf2 through a series of reactive cysteines [113-115]