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Associate Professor, Academic Unit of General Practice and Community Health, Medical School, Australian National University, Canberra, ACT Margaret Kay MBBS(Hons), PhD, FRACGP, DipRACOG, Senior Lecturer, Discipline of General Practice, The University of Queensland, Herston, QLD Hoda Hanifi, BNurs, Postgrad Dip Mental Health Nursing, Clinical Nurse, Migrant Health Service, Adelaide, SA Gauri Giri, MNurs, BSc (Hons), Nurs, Community Health Worker, Migrant Health Service, Adelaide, SA Catherine Leahy BMus/BArts (Hons Psychology), PhD Medicine, Dip Counselling, Research Academic, Health Sciences, University of Adelaide, Adelaide, SA Michelle Lorimer BSc (Math & Comp Sci)(Hons), Senior Statistician, School of Population Health, University of Adelaide, Adelaide, SA Competing interests: None

We work with each client to develop a personalized treatment plan based on their response to initial treatments, overall health goals, and budget considerations

Because the deacetylase activity of sirtuins is strictly NAD + -dependent 30 , we examined the impact of CD38 inhibition on sirtuin function

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