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Furthermore, brown adipose tissue (BAT) is a mitochondria rich tissue with high oxidative capacity which have been implicated in the process of adaptive thermogenesis (Lettieri-Barbato, 2019)

B.BurrinJ

Telehealth providers ship from out of state, often without lab work or in-person evaluation

As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication