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They are often discussed as investigational compounds in medical and research contexts

The BeautyBrains blog made a fantastic article about ceramides and they have listed a couple of examples about studies showing that ceramides - especially when used in certain ratios with cholesterol and fatty acids - do hydrate the skin and can help to repair the skin barrier

Insulin Syringes (U-100) 0.3 mL / 30-unit syringes align cleanly with a 1 mg dose when a 10 mg vial is mixed with 3.0 mL BAC water (30 units)

Oral versions such as capsules or troches are more convenient, but absorption through the digestive tract is far less consistent, so the amount that actually reaches circulation can vary widely