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doi: 10.3389/fmicb.2023.1122623 Received 13 December 2022 Accepted 07 March 2023 Published 22 March 2023 Volume 14 - 2023 Edited by Peng Fei, Nanyang Institute of Technology, China Reviewed by Brandan Pedre Perez, KU Leuven, Belgium

Coincidentally, in the current study population, 7 of 13 subjects for whom a pathogenic mutation had been identified had a mutation in Ush2A

To further expand coverage of metabolites in the isotopologue similarity network, methods such as chemical derivatization and multidimensional chromatography separation can also be employed

For example, its involved in the synthesis of the inflammatory mediators leukotrienes and prostaglandins