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What remains unclear is whether those mechanisms translate to symptom relief in humans with reflux disease

[93] In addition to its activity as a SERM, tamoxifen is a potent and selective protein kinase C inhibitor, and is active in this regard at therapeutic concentrations

Additionally, it helps protect the heart and central nervous system from oxidative damage

Response: We emphasize that our intent is to ensure that practitioners have flexibility in how they satisfy the care plan requirement, including who drafts the care plan, what elements are included, and as mentioned above, at what frequency they are updated