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The Nrf2 expression in the nuclear fraction was increased by fisetin which also increased the mRNA and protein expression of HO-1 in turn decreasing the activity of MMP-2 and MMP-9

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Certification: The undersigned certifies, that, to the best knowledge and belief of the undersigned, this petition includes all information and views on which the petition relies, and that it includes representative data and information known to the petitioner which are unfavorable to the petition

Like all enzymes, phosphoglycerate kinase can catalyze the reaction in both directions