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it has been the subject of extensive research for decades

Abstract Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease

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Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to healthcare providers