glutathione-s-transferase from the pathogenic fungus coccidioides immitis Fungal Phagocytosis in Absence of Oxidative Stress Response Proteins Coccidioides immitis Schematic representation of the structure

the pharmacokinetics and biodistribution of the GSH-targeted liposomes was visualized by analysis of the Rho-PE label in the liposomes after 12 daily intravenous bolus injections in hamsters, and compared to the un-targeted liposomes

these effects were abolished by antibiotic intervention (Qian J

10.1038/nnano.2016.23 Nat

As it is overexpressed in the prostate tumor site but rapidly inactivated in systemic circulation due to binding to serum protease inhibitors like 2-macroglobulin (A2M) and 1-antichymotrypsin (ACT), PSA is considered an attractive target for small molecule prodrugs against prostate cancer (Lilja et al., 1991