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Excessive generation of ROS within ovarian, adipose, and hepatic tissues overpowers antioxidant defenses, leading to oxidative damage of lipids, proteins, and mitochondrial DNA ( Androgen excess exacerbates redox disequilibrium by promoting NADPH oxidase activity and mitochondrial ROS production, while simultaneously impairing follicular maturation and oocyte quality (77)

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The frequency of taking ULD and colchicine, which were more often prescribed to patients with gout, differed as expected (p 2 mg/l)

Although there is restricted exchange between the cytoplasmic and mitochondrial pools of THF molecules, these compartments are metabolically connected by transport of the one-carbon donors (serine, glycine, and formate) across the mitochondrial membranes