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However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)

Content : 30 capsules FDA Registration Number : 13-1-02954-1-0130

1,12 [corrected] Clinical evaluation seems to show an inverse relationship between the severity of megaloblastic anemia and the degree of neurologic impairment

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Maret W., Larsen K.S., Vallee B.L