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Coexpression network analysis reveals integrated regulatory mechanisms The further co expression analysis of genes, metabolites, and TFs networks within glutathione, phenylpropanoid, and flavonoid biosynthesis pathways identified a highly interconnected network showing an intertwined regulatory complex

4,6 The present study has demonstrated that citicoline increases glutathione levels after transient forebrain ischemia, which could increase the scavenging of oxygen radicals by GSH

Regarding the relationship between amino acid metabolism and CHD, several studies have evidenced the crucial roles of specific amino acids

Indeed, two of the genes encoding the main ATP-dependent cation pumps, ATP1A2 and ATP1A3 , are in our paroxysmal gene list and were determined to be Highly likely to be CVS related due to multiple case reports in the literature associated with intermittent vomiting