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doi: 10.1016/j.jphs.2021.10.010

Other stimuli may cause acute and chronic alterations in endothelium permeability, such as the vascular endothelial growth factor (VEGF), thrombin, and histamine release, as well as acute inflammation regulators such as tumor necrosis factor- (TNF-) and interleukin 1b (IL-1b)

Although the peptide substrate PCa-5791 is rather specific for APC, this substrate is hydrolyzed in the presence of low nanomolar concentration of thrombin which might conceal the detection of APC generation in the activation mixture (see Supplementary Fig

Scores were computed using the AddModuleScore function