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Description

A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself

doi:10.1002/jor.21107 Japjec M, Pavlov KH, Petrovic A, et al

In addition, previously described CNVs containing genes such as SHANK3 , MBP , CHL1 , and others have been identified [6]

Adults who are lean, experience rapid progression to insulin requirement, or test positive for islet autoantibodies may have latent autoimmune diabetes in adults (LADA), which behaves more like Type 1 than Type 2 and eventually requires insulin