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Dark circles under the eyes in 12-year-olds can occur for different reasons than in adults and are often considered a physiological condition

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The sub-threshold doses of HGF and Dihexa combined, however, appeared to produce an effect similar to the saturating doses of HGF and Dihexa (p 0.05 by one-way ANOVA followed by Tukey post hoc test) as shown in Figure 20