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Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority

Faster Recovery: With enhanced antioxidant defenses and detoxification support, patients may experience shorter recovery times and fewer complications

One is from not getting enough vitamin B12 through the diet