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Saleh et al., 2016), as well as GABA, GSH and ethanol(Saleh, Wang, et al., 2020)

Kojic acid works by blocking tyrosine from forming, which then prevents melanin production

To date, three small-molecule Nrf2 activators (dimethyl fumarate [DMF], diroximel fumarate and omaveloxolone) have already been approved by the US Food and Drug Administration for specific indications (multiple sclerosis, psoriasis and Friedreichs ataxia), while numerous others under preclinical investigation