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PMID: 24153250

IV zinc differs in several ways: Delivered directly into circulation Avoids gastrointestinal irritation Allows for predictable absorption Can be combined with hydration and other supportive nutrients IV administration may be considered when oral intake is insufficient, poorly tolerated, or ineffective in meeting short-term physiological demand

Observed adverse effects are mild: nasal irritation from intranasal delivery, transient headache, and in semax specifically, a modest increase in blood glucose in diabetic patients in one study