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Bibcode:2015Natur.517..513P

99 JoeE.-H.ChoiD.-J.AnJ.EunJ.-H.JouI.ParkS

It was further observed that the variation in relative mean shifts in TW CCS N2, meas values was significantly increased for phase II compared to phase I biotransformations which was somehow expected: simple modifications following phase I reactions typically introduce relatively small changes in the molecular structure of the parent drug resulting in fairly consistent shifts in relative TW CCS N2, meas values (except for major dealkylations within the molecule)