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Acute sleep-wake cycle shift results in community alteration of human gut microbiome

Zainol et al., 2023

Pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-6, IL-17, and interferon-gamma dominate, while anti-inflammatory cytokines like IL-10, IL-4, and TGF-beta are insufficient to restore immune homeostasis

The data revealed that SNRI-treated patients with elevated AST levels were approximately 9.16 times more likely to experience a relapse (p = 0.028), while those with elevated GGT levels faced a 5.34 times higher risk (p = 0.018)