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Perturbations in mitochondrial dynamics can affect many cellular and molecular pathways, particularly during inflammation [15] (for reviews, see [33, 116])

10.1038/s12276-023-00971-9 83 JinL.ChunJ.PanC.KumarA.ZhangG.HaY.et al (2018)

At that time, the organoids were left untreated or treated with 10 nM of the non-aromatizable androgen R1881 43 , in the absence or presence of 10 M of the AR-antagonist, enzalutamide 44 , or 10 nM of the stapled peptide, Rh-2025u

In individual cases where the severity and frequency of the seizure disorder are such that the removal of medication does not pose a serious threat to the patient, discontinuation of the drug may be considered prior to and during pregnancy, although it cannot be said with any confidence that even minor seizures do not pose some hazard to the developing embryo or fetus [see Boxed Warning and Use in Specific Populations (8.1)]