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These include vaccine-based and immune-stimulatory approaches evaluated in the adjuvant setting, such as booster peptide vaccination in previously vaccinated patients with resected melanoma (NCT01989559, completed) and a randomized phase III trial testing sargramostim (GM-CSF), peptide vaccination, or their combination following surgical resection of high-risk disease (NCT01989572, completed)

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Gut microbiota is involved in the synthesis of biological metabolites in the digestive tract [53]

This is not an exhaustive list of possible drug interactions

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