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Research Square PrintOctober 10th, 2022

[33] [26] [116] It is also contraindicated in individuals with advanced arteriosclerosis (hardening of the arteries), glaucoma (increased eye pressure), hyperthyroidism (excessive production of thyroid hormone), or moderate to severe hypertension

BNIP3 3D structure modelling The structure of BNIP3 was modelled using Modeller 9.15 29

Through an unknown mechanism, the enzyme glutamic-oxaloacetic transaminase 1 (GOT1) subsequently converts glutamate to a-ketoglutarate (a-KG), which causes ROS buildup and starts ferroptosis [67]