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Long-lasting pain often means that several mechanisms are active at the same time: nerve irritation, medication tolerance, peripheral branch hypersensitivity, previous dental or surgical trauma, viral nerve injury, muscle spasm, or central sensitization

Similar to previous studies in salivary glands (Avila et al , 2009), we found a 10 Gy dose induces DNA damage and cell cycle arrest, as well as reduces cell proliferation in the SLG in the first day following IR, as shown by a substantial increase in the proapoptotic gene Bax and the cell cycle inhibitor Cdkn1a (p21) (Fig EV4A) and a reduction in transcript levels of the cell proliferation marker Mki67 (Fig EV4A)

Both Triamcinolone and Cortisone are corticosteroids and work through similar mechanisms

No adverse fetal effects have been documented from normal therapeutic doses of hydroxocobalamin in human pregnancies