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Berson gives us a masterclass in the nervous systemone that, in just less than two hours, will teach you an entire course's worth about the brain and how yours works

It appears that extensive oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids might modify membrane structure and increase membrane permeability, eventually resulting in plasma membrane rupture in response to accumulation of lipid-ROS, e.g., lipid hydroperoxides

Pyridoxine (vitamin B6) was also administered for the prophylaxis of HFS

Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose)